Steroid Hormone Biosynthesis Service

v-innovate Technologies is a pioneer in metabolism service and provides reliable, professional and cost-effective steroid hormone biosynthesis analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of steroid hormone biosynthesis analysis in animal.

Overview

Steroid hormones are lipid molecules synthesized within the ovary, testis, placenta and adrenal cortex. Steroid hormones can be classified into two classes: corticosteroids and sex steroids. Within those two classes are five types according to the receptors to which they bind: glucocorticoids and mineralocorticoids and androgens, estrogens, and progestogens. Vitamin D derivatives are a sixth closely related hormone system with homologous receptors. Steroid hormones play important roles in metabolism, growth and differentiation and in reproductive functions. The precursor of all steroid hormones is cholesterol which is derived from diet or via in vivo synthesis from acetyl-CoA. The synthesis and release of steroid hormones are intensively regulated by the hypothalamus-pituitary-adrenal axis. The steroid hormone biosynthesis aberrations are closely associated with various human pathologies like congenital adrenal hyperplasia and aromatase excess syndrome. Understanding the steroid hormone biosynthesis is beneficial for unravelling the underlying mechanism behind human diseases. In v-innovate Technologies, we provide reliable, rapid and cost-effective steroid hormone biosynthesis related service to speed up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Steroid Hormone Biosynthesis Service

Identifying novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of novel drugs

Gaining new mechanism of diseases

Advantages of Our Steroid Hormone Biosynthesis Service

Constantly optimized protocol and analytical software

Professional experiment design

Quick turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

v-innovate Technologies provides steroid hormone biosynthesis analysis service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Figure 1. The overall workflow of steroid hormone biosynthesis.

List of Partial Detectable Steroid Hormone Metabolism Related Metabolites at v-innovate Technologies

Progesterone	17α-Hydroxyprogesterone	Corticosterone	Androgens	Deoxycortisol
Estrogens	17α-Hydroxypregnenolone	Testosterone	Androstenedione	Pregnenolone
Oestradiol	Dehydroepiandrosterone	Cortisol	Aldosterone	Oestrone

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the following requirements for different types of sample:

• Blood/plasma: 500ul/sample
• Urine: 1ml/sample
• Tissue: 200mg/sample
• Cells: 1x10⁷/sample
• Feces: 500mg/sample
• Shipment condition: dry ice

Report Delivery

• Experimental protocols
• Instrumental factors of HPLC
• The raw data files of HPLC and the summary of HPLC data quality
• Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of steroid hormone biosynthesis, professional bioinformatic analysis software and experienced technicians and scientists, v-innovate Technologies provides customer-tailored steroid hormone biosynthesis analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

1. Lin-Su Karen, Nimkarn Saroj, New Maria I. Congenital adrenal hyperplasia in adolescents: diagnosis and management. Ann N Y Acad Sci. 2008.1135:95-98.
2. Demura Masashi, Martin Regina M, Shozu Makio, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene. Hum Mol Genet. 2007.16:2529-2541.