Butanoate Metabolism Service

v-innovate Technologies, as a leading biotechnology company, provides reliable, fast and cost-effective butanoate metabolism analysis service for animal related materials. We leverage our ample experience, professional expertise, and advanced technologies to speed up your scientific purposes of butanoate metabolism analysis in animal.

Overview

Butanoate is the conventional name for the conjugate base of butyric acid. The formula of the butyrate ion is C₄H₇O₂. The name now is used as part of the name of esters and carboxylate salts of butyric acid. Endogenous butanoate is majorly produced from dietary fibres through bacterial fermentation in gut. Therefore, butanoate plays important roles in regulating colonic inflammation and gut immunological homeostasis. In addition, butanoate can influence on various physiological functions like increasing energy expenditure and reducing adiposity via its metabolites. It would not be surprising that aberrant butanoate metabolism is closely associated with different types of diseases including L-2-hydroxyglutaric aciduria and 3-Hydroxyacyl-CoA dehydrogenase deficiency. Understanding butanoate metabolism related metabolites will contribute to diagnosing these abnormal diseases and identifying potential targets for treatments. As a pioneer in carbohydrate metabolism, v-innovate Technologies provides reliable, rapid and cost-effective butanoate metabolism analysis service to speed up diseases diagnosis and gain new insights in disease mechanism or treatment.

The Major Applications of Butanoate Metabolism Service

Discovering novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of drugs

Gaining new mechanism of metabolic diseases

Advantages of Our Butanoate Metabolism Service

Rich experience in a variety of animal sample preparation

State of the art facilities

Professional experiment design and data analysis

Low cost

Short experimental time

High accuracy, specificity, and sensitivity

Service Workflow

v-innovate Technologies provides butanoate metabolism service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four major steps: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Figure 1. The overall workflow of butanoate metabolism service.

The potential Detectable Butanoate Metabolism related metabolites at v-innovate Technologies

Butanoyl-CoA	Crotonoyl-CoA	Butanal
Hydroxybutanoyl-CoA	Acetoacetyl-CoA	Hydroxyglutarate
Acetoacetate	Butanoyl-phosphate

Sample Requirements

We can analyze a wide range of biological materials ranging from animal cells to animal solid tissues. If you need transport your samples to us, please follow the below requirements for different kinds of sample:

• Blood/plasma: 500ul/sample
• Urine: 1ml/sample
• Tissue: 200mg/sample
• Cells: 1x10⁷/sample
• Feces: 500mg/sample
• Shipment condition: dry ice

Report Delivery

• Experimental procedures
• Instrumental parameters of HPLC
• The raw data files of HPLC and the summary of HPLC data quality
• Bioinformatics analysis report

Equipped with advanced HPLC platforms for the determination of butanoate metabolism, professional bioinformatic analysis software and experienced technicians and scientists, v-innovate Technologies provides customer-tailored butanoate metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

1. Liu Hu, Wang Ji, He Ting, et al. Butyrate: A Double-Edged Sword for Health? Adv Nutr. 2018,9:21-29.
2. Rzem Rim, Veiga-da-Cunha Maria, Noël Gaëtane,  et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria. Proc Natl Acad Sci USA. 2004, 101:16849-16854.
3. Yang Song-Yu, He Xue-Ying, Schulz Horst. 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease. FEBS J. 2005, 272:4874-4883.