Acenocoumarol Analysis Service

Acenocoumarol is an anticoagulant that is being developed to prevent complications associated with atrial fibrillation, prosthetic heart valves, and thromboembolic diseases such as deep vein thrombosis and pulmonary embolism. v-innovate Technologies can provide you with acenocumarol content testing based on high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) technology.

Overview

Acenocoumarol is a synthetic substitute for bicoumarol and is chemically similar to vitamin K. It is used clinically for the prevention and treatment of vascular thrombotic disorders such as venous thrombosis, pulmonary embolism, myocardial infarction and embolism-induced atrial fibrillation. Due to the wide presence and use of acenocoumarol, it is important to establish analytical methods for acenocoumarol in plant metabolites, drugs, and chemicals for daily use. v-innovate Technologies offers high precision, high resolution HPLC-MS/MS equipment for qualitative and quantitative acenocoumarol analysis. The use of tandem mass spectrometry and stable isotope internal standards allows the development of highly sensitive and accurate analytical methods to minimize ion suppression effects.

Applications of Acenocoumarol Analysis

• Qualitative analysis of the main types of acenocoumarol
• Quantitative analysis of acenocoumarol content
• Ensure safety and quality
• Provide basis for improvement

Advantages of Our Acenocoumarol Analysis Service

Rich experience in sample handling. Coumarins are diverse and have similar structures, so sample handling and extraction are very important for identification and analysis results. We have a complete laboratory network and professional technicians to provide reliable targeted metabolomics service.

High cost performance. Our laboratories can provide a one-stop-shop to save you time. Comprehensive project analysis solutions also deliver the best value for money.

Strong analytical skills. With many years of experience in HPLC-MS/MS service, v-innovate Technologies can quickly and accurately analyze the mass spectrometry results and conduct professional analysis.

Service Workflow

Our newly developed sample preprocessing method provides safety, environmental protection, rapidness, effectiveness, and the recovery rate is between 85% and 105%. Sample preprocessing at v-innovate Technologies complies with the in-house standard operation procedures (SOP), ensuring maximized homogeneity between samples.

 Figure 1. Acenocoumarol analysis service workflow.

Extracting agent: Absolute ethyl alcohol

Linear range: RSD 0.4%-1.0%; r>0.999

Time: dozens of minutes, slightly different according to different ingredients

Analysis content:

• Standard curve creation
• Raw data preprocessing
• Absolute quantitation of acenocoumarol
• Differential metabolites screening
• Optimal analysis

Sample Requirements

• Tissue ≥ 200 mg/sample
• Plasma ≥ 200 μL/sample
• Blood ≥ 200 μL/sample
• Drugs ≥ 0.2 g/sample

We also accept other samples. Our technician will communicate with you about specific sample requirements.

In order to ensure the accuracy of the samples and reduce systematic errors during sampling, it is necessary to select more than 3 materials with the same condition for each sample. The same condition refers to the same period, basically the same phenotype, and the same part.

Delivery

• Experimental procedure
• Parameters of HPLC-MS/MS
• HPLC-MS/MS raw data files and HPLC-MS/MS data quality checks
• Metabolites quantification data
• Custom analysis report

v-innovate Technologies is pleased to assist you with the identification and quantitative analysis of acenocoumarol to assist in your research. If you need to analyze other compounds, please contact us.